Line a 15-in. x 10-in.x 1-in. baking pan with foil; coat the foil with nonstick cooking spray. Place pretzels in a large bowl. In a small bowl, combine the honey, butter, onion powder and chili powder. Pour over pretzels; toss to coat evenly. Spread into prepared pan. Bake at 350 degrees F for 8 minutes, stirring once. Cool on a wire rack, stirring gently several times to separate.